Osteoprotegerin
US6369027B1 · kind B1 · utility
28Cited by
4References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 3, 1996 |
| Grant date | Apr 9, 2002 |
| Priority date | — |
| Expiry date | Sep 3, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.