Octacyclodepsipeptides having an endoparasiticidal action

US6369028B1 · kind B1 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Scherkenbeck · Leverkusen, DE
• Peter Jeschke · Eltville am Rhein, DE
• Hans-Georg Lerchen · Leverkusen, DE
• Hermann Hagemann · Leverkusen, DE
• Achim Harder · Leverkusen, DE
• Norbert Mencke · Leverkusen, DE
• Andrew Plant · Leverkusen, DE

Key dates

• Filing date: May 19, 1994
• Grant date: Apr 9, 2002
• Expiry date: May 19, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C235/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the general formula (I) in whichR1, R2, R11 and R12 represent the same or different radicals selected from the group of C1-8-alkyl, C1-8-halogenoalkyl, C3-6-cycloalkyl, aralkyl or aryl,R3, R5, R7, R9, represent the same or different radicals selected from the group of hydrogen or straight-chainC1-5-alkyl or branched C4-7-alkyl which may optionally be substituted by hydroxyl, C1-4-alkoxy, carboxyl  carboxamide,  imidazolyl, indolyl, guanidino, —SHor C1-4-alkylthio, and furthermore represents aryl, aralkyl or heteroarylmethyl which may be substituted by halogen, hydroxyl, C1-4-alkyl, C1-4-alkoxy, nitro or a —NR13R14 group in which R13 and R14 independently from each other represent hydrogen or alkyl or together with the adjoining nitrogen atom forms a 5, 6 or 7-membered ring which is optionally interrupted by O, S or N and which is optionally C1-4-alkyl substituted,R4, R6, R8, R10 represent the same or different radicals selected from the group of hydrogen, straight-chain C1-5-alkyl and represents isopropyl, sec.-butyl, t-butyl, C2-6-alkenyl, C3-7-cycloalkyl, which may optionally be substituted by hydroxyl, C1-4-al…