Treatment of ischemic brain injuries with brain targeted anti oxidant compounds
US6369106B1 · kind B1 · utility
33Cited by
3References
8Claims
0Family size
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Key dates
| Filing date | Dec 27, 1999 |
| Grant date | Apr 9, 2002 |
| Priority date | — |
| Expiry date | Dec 27, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0215
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.