Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor

US6369109B1 · kind B1 · utility

Assignee

• DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS · DE

Inventors

• Klaus-Michael Debatin · Heidelberg, DE
• Simone Fulda · Ulm, DE
• Manfred Wiessler · Bischofswerda, DE
• Marek Los · Heidelberg, DE
• Walter Mier · Bensheim, DE

Key dates

• Filing date: Oct 28, 1998
• Grant date: Apr 9, 2002
• Expiry date: Oct 28, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J63/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is, generally, directed to the use of betulinic acid and derivatives thereof for the treatment of neuroectodermal tumors. The present invention is based on the discovery that betulinic acid and its derivatives are potent anti-neuroectodermal agents. As disclosed herein, betulinic acid and its derivatives are useful for the treatment of neuroectodermal tumors, including, due to its distinct mechanism of action, neuroectodermal tumors that are resistant to conventional chemotherapeutical agents. In addition to the new use of known compounds, the invention discloses novel compounds and pharmaceutical compositions for the treatment of neuroectodermal tumors.