Pyridylalanine derivatives
US6369229B1 · kind B1 · utility
39Cited by
12References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 30, 2000 |
| Grant date | Apr 9, 2002 |
| Priority date | — |
| Expiry date | Mar 30, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aromatic amines of formula (1) are described: wherein Az is an optionally substituted monocyclic six-membered nitrogen-containing aromatic group;L1 is a linker atom or group;R is a carboxylic acid or a derivative thereof;and R5 is a group —L2(CH2)tR6 in which L2 is a —N(R7)CO— or —N(R7)CS-group. The compounds are able to inhibit the binding of &agr;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.