Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US6371975B2 · kind B2 · utility
253Cited by
56References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 6, 1998 |
| Grant date | Apr 16, 2002 |
| Priority date | — |
| Expiry date | Nov 6, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2090/064
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A biocompatible and biodegradable barrier material is applied to a tissue region, e.g., to seal a vascular puncture site. The barrier material comprises a compound, which is chemically cross-linked without use of an enzyme to form a non-liquid mechanical matrix. The compound preferably includes a protein comprising recombinant or natural serum albumin, which is mixed with a polymer that comprises poly(ethylene) glycol (PEG), and, most preferably, a multi-armed PEG polymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.