Pharmaceutical compositions containing antibody-enzyme conjugates in combination with prodrugs
US6372205B1 · kind B1 · utility
15Cited by
0References
39Claims
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Assignee
Inventors
Key dates
| Filing date | May 22, 2000 |
| Grant date | Apr 16, 2002 |
| Priority date | — |
| Expiry date | May 22, 2020 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Prodrugs which can be activated by enzymes, are formulated for sequential administration, with enzyme conjugates. Either or each component comprises a polymeric carrier which allows it to be directed preferentially to the target tissue. A new polymer-prodrug conjugate is cleavable by cathepsin-B or othe invention is of particular utility for targeting solid tumours.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.