Method of producing elastin, elastin-based biomaterials and tropoelastin materials
US6372228B1 · kind B1 · utility
Assignees
Inventor
Key dates
| Filing date | Dec 30, 1997 |
| Grant date | Apr 16, 2002 |
| Priority date | — |
| Expiry date | Dec 30, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for producing elastin or elastin-based materials or tropoelastin materials which have a substantially reduced level of calcification. These materials are typically capable of being formed into a fused layer. The subject method comprises providing unreacted elastin or elastin-based biomaterials or tropoelastin materials, and pretreating the unreacted elastin or elastin-based biomaterials or tropoelastin materials with an aliphatic alcohol prior to reaction thereof. In this way, when the pretreated unreacted elastin or elastin-based biomaterials or tropoelastin materials is reacted subsequently, elastin or elastin-based materials or tropoelastin materials are produced which have a substantially reduced level of calcification as compared with elastin or elastin-based materials or tropoelastin materials produced from non-pretreated counterpart unreacted elastin or elastin-based biomaterials or tropoelastin materials.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.