Coated surface comprising a polyvinyl alcohol (PVA) based covalently bonded stable hydrophilic coating
US6372353B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 23, 1998 |
| Grant date | Apr 16, 2002 |
| Priority date | — |
| Expiry date | Nov 23, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31935
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Coatings suitable for surfaces such as are found in capillary electrophoresis columns and methods for their preparation are disclosed. A coated surface of the invention, preferably an interior surface of a microcapillary, generally includes a surface having an interconnected polymeric coating that includes a functional group attached to the surface and capable of copolymerizing with an organic compound in an organic solvent, and a polymer of the organic compound copolymerized with the functional group. The coating can be covalently or non-covalently attached to the surface and can further include an additional layer of coating material. Preferably, the organic compound is a vinyl ester, and most preferably, vinyl acetate, and the attached polymer forming the exposed surface of the coating is a polyvinyl alcohol, the hydroxyl groups of which can be further derivatized in any desired manner. The coating of the invention creates a new, stable surface, appropriate for CE columns or general surface modification. The coating is stable over a wide pH range and allows highly efficient grafting and/or adsorption of a variety of additional layers, if desired.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.