Cyclic lipopeptide acylase
US6372474B1 · kind B1 · utility
2Cited by
5References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 12, 2000 |
| Grant date | Apr 16, 2002 |
| Priority date | — |
| Expiry date | Sep 12, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a cyclic lipopeptide acrylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase. [whereinR1 is acyl;R2 is hydroxy or acyloxy;R3 is hydrogen or hydroxy;R4 is hydrogen or hydroxy;R5 is hydrogen or hydroxysulfonyloxy; andR6 is hydrogen or carbamoyl]
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.