Methods, systems, and kits for intravascular nucleic acid delivery
US6372498B1 · kind B1 · utility
46Cited by
9References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 30, 1998 |
| Grant date | Apr 16, 2002 |
| Priority date | — |
| Expiry date | Dec 30, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/306
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Nucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm2 to 100 W/cm2, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.