Transgenic rats and rat cell lines expressing human CD4 and a human chemokine receptor
US6372956B1 · kind B1 · utility
24Cited by
1References
21Claims
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Key dates
| Filing date | Dec 23, 1999 |
| Grant date | Apr 16, 2002 |
| Priority date | — |
| Expiry date | Dec 23, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0337
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention features transgenic rodent models for HIV, wherein the transgenic rodent or transgenic rodent cell has incorporated into its genome genes encoding a human CD4 receptor and a human chemokine receptor. In particular the invention relates to transgenic rats, or mice characterized by being susceptible to infection with HIV, capable of expressing HIV structural genes, or HIV replication. The transgenic rodent or rodent cell of this invention is useful for studying the molecular basis of HIV infection, replication and pathogenicity, as well as for the testing of agents for new antiviral or vaccine strategies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.