Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6376179B1 · kind B1 · utility
16Cited by
14References
36Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 17, 1999 |
| Grant date | Apr 23, 2002 |
| Priority date | — |
| Expiry date | Dec 17, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for labeling a synthetic or natural ribonucleic acid (RNA). It also relates to RNA fragments, which have been labeled by fragmenting the RNA to free a terminal phosphate of each fragment for further reaction, and labeling each fragment at the freed terminal phosphate which is located at the 3′ end and/or the 5′ end of each fragment of the RNA, and to the use of such RNA fragments, for example, in the field of medical diagnosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.