High-efficiency wild-type-free AAV helper functions
US6376237B1 · kind B1 · utility
27Cited by
8References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 29, 1999 |
| Grant date | Apr 23, 2002 |
| Priority date | — |
| Expiry date | Nov 29, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.