Methods and compositions for organ decellularization
US6376244B1 · kind B1 · utility
163Cited by
27References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 29, 1999 |
| Grant date | Apr 23, 2002 |
| Priority date | — |
| Expiry date | Dec 29, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/40
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention is directed to methods for producing a decellularized organ or part of an organ. A decellularized organ is produced using an isolated organ mechanically agitated to remove cellular membranes surrounding the isolated organ without destroying the interstitial structure of the organ. After the cellular membrane is removed, the isolated organ is exposed to a solubilizing fluid that extracts cellular material without dissolving the interstitial structure of the organ. A washing fluid is used to remove the solubilized components, leaving behind a decellularized organ.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.