Rapid process for arraying and synthesizing bead-based combinatorial libraries
US6376256B1 · kind B1 · utility
102Cited by
14References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 19, 1999 |
| Grant date | Apr 23, 2002 |
| Priority date | — |
| Expiry date | Feb 19, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/255
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive layer exposed through an aperture in a mask. Beads which are trapped by the attachment areas are released either by a solvent on a vacuum manifold, or by evaporation of the adhesive, preferably by means of a vacuum centrifuge. The beads are released into capillaries, in which cleavage of attached compounds, or synthesis of new compounds, can be carried out. Also invented is the apparatus used in carrying out the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.