Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties

US6376472B1 · kind B1 · utility

Assignee

• Aventis Pharmaceuticals Inc. · US

Inventors

• Michael R. Myers · Fishers, US
• Martin P. Maguire · Westmount, CA
• Alfred P. Spada · Lansdale, US
• William R. Ewing · Yardley, US
• Henry Pauls · Collegeville, US
• Yong Mi Choi-Sledeski · Montgomery, US

Key dates

• Filing date: Oct 16, 1998
• Grant date: Apr 23, 2002
• Expiry date: Oct 16, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of the formula wherein K is N; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methylallyl, 2-butenyl, or cycloalkyl where the nitrogen of the ring of X is substituted by Y; E is O or S; Y is hydrogen, alkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, or substituted heterocyclylalkyl; and n and p are independently 0, 1, 2, or 3, provided that n+p is at least 1;T is hydrogen, alkyl, alkylcarbonyl, alkylthiocarbonyl, halo, carboxyl, A and B are independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR′;or a pharmaceutically acceptable salt thereof, a pharmaceutic-ally acceptable prodrug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.