Control of immune responses by modulating activity of glycosyltransferases
US6376475B1 · kind B1 · utility
5Cited by
5References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 29, 1998 |
| Grant date | Apr 23, 2002 |
| Priority date | — |
| Expiry date | May 29, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2217/075
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated immune responses are mediated by interfering with synthesis of &agr;2,6 sialylgalactosides, while T lymphocyte-mediated immune responses are inhibited by blocking synthesis of &agr;2,3 sialylgalactosides. The inhibition is accomplished by, for example, inhibiting the activity of a glycosyltransferase involved in synthesis of the respective sialyl galactoside.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.