Benzoxazoles with PDE-inhibiting activity

US6376485B1 · kind B1 · utility

Assignee

• Byk Gulden Lomberg Chemische Fabrik GmbH · DE

Inventor

• Thomas Martin · Konstanz, DE

Key dates

• Filing date: Jan 3, 2001
• Grant date: Apr 23, 2002
• Expiry date: Jan 3, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I in which R1, R2, R3 and A have the meaning set forth in the specification, are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors useful as therapeutics in human and veterinary medicine. They are distinguished by low toxicity, good enteral absorption (high bioavailability), a wide therapeutic breadth and absence of significant side effects.