Thrombin inhibitors

US6376499B1 · kind B1 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Philip E. Sanderson · Philadelphia, US
• Terry A. Lyle · Lederach, US
• Bruce D. Dorsey · Ambler, US
• Matthew G. Stanton · Marlton, US
• Adel M. Naylor-Olsen · Lansdale, US

Key dates

• Filing date: Oct 28, 1999
• Grant date: Apr 23, 2002
• Expiry date: Oct 28, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is N Y1 or O; c is CY2 or N; d is CY2; e is CY1 or N; f is CY1 or N; g is CY1 or N; Y1 is hydrogen, C1-4 alkyl, or halogen; Y2 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy;A is  and W, X, Z, R3, R4 and R5 are defined in the specification.