Patent · US Expired

1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2

US6376519B1 · kind B1 · utility

7Cited by

20References

47Claims

0Family size

Assignee

TEMPLE UNIVERSITY-OF THE COMMONWEALTH OF HIGHER EDUCATION · US

Inventors

E. Premkumar Reddy · Villanova, US
M. V. Ramana Reddy · Upper Darby, US

Key dates

Filing date	Jun 16, 2000
Grant date	Apr 23, 2002
Priority date	—
Expiry date	Jun 16, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D403/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds of the formula wherein:X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula II: wherein:R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl;C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano;Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.