Bioactive derivatives of camptothecin
US6376617B1 · kind B1 · utility
3Cited by
6References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 3, 1999 |
| Grant date | Apr 23, 2002 |
| Priority date | — |
| Expiry date | Jun 3, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/65
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Water soluble polymeric conjugates of camptothecin consist essentially of N-(2-hydroxypropyl)methacryloylamide units linked via a spacer group to a residue of a camptothecin such as irinotecan or its non-soluble metabolite, 7-ethyl-10-hydroxy-camptothecin. The conjugates possess enhance antitumor activity and decreased toxicity with respect to the free drug. A process for their preparation and the pharmaceutical compositions containing them are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.