Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
US6377057B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 18, 1999 |
| Grant date | Apr 23, 2002 |
| Priority date | — |
| Expiry date | Feb 18, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/4836
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Biologically active compounds are classified according to their effect on ion channels, changes in membrane potential and ionic currents, and the frequency content of action potentials that the compound(s) evoke in excitable cells. The spectral density changes of such evoked membrane potential or action potential are a characteristic for each channel type that is modulated by the test compound. A pattern of spectral changes in membrane potential is determined by contacting a responsive cell with a compound, and monitoring the membrane potential or ionic currents over time. These changes correlate with the effect of that compound, or class of compounds, on the ion channels of the responding cell. This pattern of spectral changes provides a unique signature for the compound, and provides a useful method for characterization of channel modulating agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.