Process for the fermentative preparation of L-amino acids using coryneform bacteria

US6379934B1 · kind B1 · utility

Assignee

• Degussa AG · DE

Inventors

• Yvonne Tilg · Wuppertal, DE
• Bernd Eikmanns · Ulm, DE
• Lothar Eggeling · Jülich, DE
• Hermann Sahm · Jülich, DE
• Bettina Mockel · Bielefeld, DE
• Walter Pfefferle · Bodenwerder, DE

Key dates

• Filing date: Jul 29, 1999
• Grant date: Apr 30, 2002
• Expiry date: Jul 29, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/77
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides a process for the fermentative preparation of L-amino acids using coryneform bacteria, in which the subunit carrying the biotin-carboxyl carrier protein domain and the biotin-carboxylase domain of the nucleotide sequence encoding the enzyme acetyl-CoA carboxylase (accBC gene) is amplified, in particular is overexpressed.