Synthetic proteins for in vivo drug delivery and tissue augmentation
US6380154B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 24, 1997 |
| Grant date | Apr 30, 2002 |
| Priority date | — |
| Expiry date | Feb 24, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2389/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method and compositions are provided which are useful for delivering a biologically active substance to a localized site in vivo and for altering the physical dimensions of a body tissue. These method and compositions employ protein polymers having varying ratios of elastin-like collagen-like, keratin-like repeating units and repeating units which promote protein crystallization such as silk-like repeating units. By varying the length of segments of the repeating units and/or the concentration of the protein polymers in the composition, the rate of delivery of a biologically active substance to a localized site can be greatly varied. Moreover, because the compositions are capable of acquiring a non-liquid form under normal physiological conditions, they find use as biocompatible tissue augmentation products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.