2-cyclohexyl quinazoline NMDA/NR2B antagonists

US6380205B1 · kind B1 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Wayne Thompson · Lansdale, US
• David A. Claremon · Audubon, US
• Peter M. Munson · Harleysville, US
• John A. McCauley · Maple Glen, US

Key dates

• Filing date: May 21, 2001
• Grant date: Apr 30, 2002
• Expiry date: May 21, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-substituted cyclohexanes substituted in the 1-position with quinazoline either directly or through a C1-C4alkyl, C1-C4alkenyl, C1-C4alkynyl, C1-C4alkoxy, amino, aminoC1-C4alkyl, hydroxyC1-C4alkyl, carbonyl, cycloC3-C6alkyl or aminocarbonyl chain are effective as NMDA NR2B antagonists useful for relieving pain.