6-substituted pyrimidine 3-oxides for promoting pigmentation of the skin/hair
US6380263B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1997 |
| Grant date | Apr 30, 2002 |
| Priority date | — |
| Expiry date | Sep 17, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q5/065
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pigmentation of human skin and/or hair is promoted by administering to individuals in need of such treatment, advantageously topically, an effective tyrosinase activity-stimulating amount of at least one 6-substituted pyrimidine 3-oxide having the structural formula (I): in which R1 and R2, which may be identical or different, are each a hydrogen atom or a C1-C12 alkyl radical; and R3 and R4, which may be identical or different, are each a C1-C12 alkyl radical or, when taken together, form a heterocycle with the nitrogen atom from which they depend, with the proviso that, when R3 and R4, taken together, form a piperidino ring, then at least one of the radicals R1 or R2 must be other than a hydrogen atom.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.