Cell-lineage specific expression in transgenic zebrafish
US6380458B1 · kind B1 · utility
24Cited by
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38Claims
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Key dates
| Filing date | Jun 9, 1997 |
| Grant date | Apr 30, 2002 |
| Priority date | — |
| Expiry date | Jun 9, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are transgenic fish, and a method of making transgenic fish, which express transgenes in stable and predictable tissue- or developmentally-specific patterns. The transgenic fish contain transgene constructs with homologous expression sequences. Also disclosed are methods of using such transgenic fish. Such expression of transgenes allow the study of developmental processes, the relationship of cell lineages, the assessment of the effect of specific genes and compounds on the development or maintenance of specific tissues or cell lineages, and the maintenance of lines of fish bearing mutant genes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.