Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6383471B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 6, 1999 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Apr 6, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/4858
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier. The carrier includes an ionizing agent capable of ionizing the functional group, a surfactant, and optionally solubilizers, triglycerides, and neutralizing agents. The invention further relates to a method of preparing such compositions by providing a composition of an ionizable hydrophobic therapeutic agent, an ionizing agent, and a surfactant, and neutralizing a portion of the ionizing agent with a neutralizing agent. The compositions of the invention are particularly suitable for use in oral dosage forms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.