Composition comprising midkine or pleiotrophin protein and method of increasing hematopoietic cells
US6383480B1 · kind B1 · utility
3Cited by
7References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 7, 1999 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Jan 7, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/23
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.