Method for producing &agr;-hydroxy acid from &agr;-hydroxy nitrile using nitrilase
US6383786B1 · kind B1 · utility
26Cited by
10References
4Claims
0Family size
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Key dates
| Filing date | Sep 7, 2001 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Sep 7, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/78
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for producing &agr;-hydroxy acids using an enzyme catalyst having nitrilase activity. More specifically, the invention pertains to use of Acidovorax facilis 72W (ATCC 55746) nitrilase to hydrolyze glycolonitrile to glycolic acid. Glycolonitrile is reacted in an aqueous mixture with a catalyst having Acidovorax facilis 72W nitrilase activity to give glycolic acid selectively, and at high concentration and high yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.