Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 · kind B1 · utility
18Cited by
13References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 14, 1999 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Apr 14, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are compounds of the formula (1): whereinR′ is hydrogen, methyl or NH2C(O)CH2—;R″ and R′″ are independently methyl or hydrogen;R and Ry are independently hydroxy or hydrogen;R1 is hydroxy, hydrogen, or hydroxysulfonyloxy;R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy;R2 is a acyl side chain. Also provided are formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R═H) forms of the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.