Bicyclic amino derivatives and PGD2, antagonist containing them
US6384075B1 · kind B1 · utility
4Cited by
7References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 18, 2000 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Feb 18, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the formula (I): wherein: for example, a compound below: wherein:R1 is CH3, H or Na; and X1—X2—X3 is: or its salt or a hydrate thereof is useful as PGD2 antagonist and can be used as a drug for treating diseases in which mast cell dysfunction is involved, for example, systemic mastocytosis and disorder of systemic mast cell activation, and also tracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria, injury due to ischemic reperfusion, and as an anti-inflammatory agent. It is particularly useful in the treatment of nasal occlusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.