Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
US6384224B2 · kind B2 · utility
1Cited by
11References
7Claims
0Family size
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Key dates
| Filing date | Jul 2, 2001 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Jul 2, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are compounds of the formula: or pharmaceutically acceptable addition salts thereof, wherein:X, Y and Z are the same or different and represent optionally substituted carbon or nitrogen;R1 and R2 independently represent organic or inorganic substituents;R3 and R4 are variables independently representing inorganic or organic substituents;A represents C1-C4 alkylene; andR5, R6, and R7 independently represent hydrogen or C1-C6 alkyl, which compounds bind selectively with high affinity to the dopamine D4 receptor subtype and are therefore of use in treatment of various neuropsychological disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.