Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
US6384227B2 · kind B2 · utility
37Cited by
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Key dates
| Filing date | Dec 18, 2000 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Dec 18, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An optically-enrichedpiperidine-2-carboxanlidecompound, in which the piperidine is optionally N-alkylated, is racemized by heating the compound in an aqueous medium, provided that the medium includes an organic co-solvent if the compound is N-alkylated. This process is particularly valuable, in conjunction with a resolution process, for the manufacture of levobupivacaine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.