Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
US6384279B1 · kind B1 · utility
6Cited by
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11Claims
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Key dates
| Filing date | Aug 30, 2001 |
| Grant date | May 7, 2002 |
| Priority date | — |
| Expiry date | Aug 30, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D257/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene) to yield the tetraamido macrocycle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.