Biofunctional surface modified ocular implants, surgical instruments, medical devices, prostheses, contact lenses and the like
US6387379B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 28, 1994 |
| Grant date | May 14, 2002 |
| Priority date | — |
| Expiry date | Feb 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC03C2218/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for modifying the surface of a material adapted for contact with tissue of a human or non-human animal to impart biofunctional, bioactive or biomimetic properties to the surface comprising:(a) exposing the surface to a solution comprising (1) an ethylenically unsaturated monomer or mixture thereof capable, via the ethylenic unsaturation, of gamma irradiation or electron beam induced polymerization, and (2) at least one biofunctional agent; and(b) irradiating the surface with gamma or electron beam irradiation in the presence of the solution to thereby form on the surface a graft polymerized coating, the coating having physically entrapped therein or chemically bonded thereto molecules of the at least one biofunctional agent which imparts biofunctional or biomimetic properties to the surface;wherein the gamma or electron beam irradiation induced polymerization is conducted under one of the following conditions:A.(i) monomer concentration in the solution in the range of from about 0.1% to about 50%, by weight;(ii) total gamma or electron beam dose in the range of from about 0.001 to less than about 0.50 Mrad; and(iii) gamma dose rate in the range of from about 10 to about 2,…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.