Composition and method of preparing microparticles of water-insoluble substances
US6387409B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 4, 2000 |
| Grant date | May 14, 2002 |
| Priority date | — |
| Expiry date | Jan 4, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/926
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and procedures that yield sub-micron and micron-size stable particles of water-insoluble or poorly soluble drugs or other industrially useful insoluble compounds are prepared using combinations of natural or synthetic phospholipids, a charged surface modifier such as a highly purified charged phospholipid and a block copolymer coated or adhered onto the surfaces of the water insoluble-compound particles. The combination of charged surface modifier and block copolymer allows the formation and stabilization of the sub-micron and micron size compound particles—stabilized by the charged phospholipid to provide electrostatic stabilization and the block copolymer to provide steric stabilization—and therefore prevents these particles from particle growth, aggregation or flocculation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.