Process for the preparation of optically active amines

US6387692B1 · kind B1 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Uwe Stelzer · Burscheid, DE
• Claus Dreisbach

Key dates

• Filing date: Jun 1, 1998
• Grant date: May 14, 2002
• Expiry date: Jun 1, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C235/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for preparing optically (S) and (R) active amines of the formula (I*) comprising reacting racemic amines corresponding to formula (I*) with esters of the formula: in the presence of lipase from Candida antarctica, and separating the (S)-amine directly from the resulting mixture, and separating the (R)-amine indirectly from the resulting mixture by reacting the acylated (R)-amine therein, which has the formula: with acid or base, wherein all the formula above, the variables are as defined herein. Certain precursors of the formula (III) are also disclosed.