Redox and photoinitiator systems for priming for improved adherence of gels to substrates

US6387977B1 · kind B1 · utility

Assignees

• Focal, Inc · US
• The Board of Regents of the University of Texas System · US

Inventors

• Amarpreet S. Sawhney · Lexington, US
• David A. Melanson · Hudson, US
• Chandrashekar P. Pathak · Lexington, US
• Jeffrey A. Hubbell · Austin, US
• Luis Z. Avila · Arlington, US
• Mark T. Kieras · Burlingame, US
• Stephen D. Goodrich · Woburn, US
• Shikha P. Barman · Lowell, US
• Arthur J. Coury · Windom, US
• Ronald S. Rudowsky · Plymouth, US
• Douglas Weaver · Bedford, US
• Marc-Alan Levine · Pottstown, US
• John Spiridigliozzi · Dedham, US
• Thomas S. Bromander · Andover, US
• Dean M. Pichon · Arlington, US
• George E. Selecman · Marblehead, US
• David J. Nedder · Attleboro, US
• Bradley C. Poff · White Bear Lake, US
• Donald Elbert · Chesterfield, US

Key dates

• Filing date: Jul 14, 2000
• Grant date: May 14, 2002
• Expiry date: Jul 14, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S602/904
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the…