Preparation method of arbutin intermediates
US6388103B2 · kind B2 · utility
2Cited by
1References
8Claims
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Key dates
| Filing date | Apr 20, 2001 |
| Grant date | May 14, 2002 |
| Priority date | — |
| Expiry date | Apr 20, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention is related to a preparation method of arbutin intermediate (chemical formula I). It is characterized by the glycosylation of hydroquinone or mono-protectected hydroquinone (chemical formula II) with pentaacetyl-&bgr;-D-glucose (chemical formula III) in the presence of Lewis acid and base as catalysts. where Ac is acetyl group, R is hydrogen, alkyl or cycloalkyl group with 1 to 10 carbon, or aliphatic or aromatic acyl group with 1 to 10 carbon.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.