System for rendering substantially non-dissoluble bio-affecting agents bio-available
US6391338B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 21, 1998 |
| Grant date | May 21, 2002 |
| Priority date | — |
| Expiry date | Aug 21, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (“bio-available”) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.