Reagents and methods useful for detecting diseases of the prostate

US6391543B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Patricia Billing-Medel · Gurnee, US
• Maurice Cohen · Miami, US
• Tracey Colpitts · Round Lake, US
• Paula Friedman · Deerfield, US
• Julian Gordon · Lake Bluff, US
• Edward Granados · Vernon Hills, US
• Steven Hodges · Buffalo Grove, US
• Michael Klass · Libertyville, US
• Jon Kratochvil · Wildwood, US
• Lisa Roberts-Rapp · Gurnee, US
• John Russell · Pleasant Prairie, US
• Stephen D. Stroupe · Libertyville, US

Key dates

• Filing date: Apr 23, 1998
• Grant date: May 21, 2002
• Expiry date: Apr 23, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS118 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS118-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS118 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.