Human chemokine beta-10 mutant polypeptides

US6391589B1 · kind B1 · utility

Assignees

• HUMAN GENOME SCIENCES, INC. · US
• SmithKline Beecham Limited · US

Inventors

• Henrik Olsen · Gaithersburg, US
• Haodong Li · Gaithersburg, US
• Mark D. Adams · Potomac, US
• Solange Gentz · Belo Horizonte, BR
• Ralph Alderson · Gaithersburg, US
• Yuling Li · Germantown, US
• David Parmelee · Rockville, US
• John R. White · Wadsworth, US
• Edward Appelbaum · Blue Bell, US

Key dates

• Filing date: Jan 7, 2000
• Grant date: May 21, 2002
• Expiry date: Jan 7, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.