Modified modular PKS with retained scaffold

US6391594B1 · kind B1 · utility

Assignees

• Kosan Biosciences Incorporated · US
• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Chaitan Khosla · Stanford, US
• Gary Ashley · Alameda, US
• Hong Fu · Chongqing, CN
• Camilla Kao · Palo Alto, US
• Robert McDaniel · Palo Alto, US

Key dates

• Filing date: Apr 30, 1997
• Grant date: May 21, 2002
• Expiry date: Apr 30, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds.