Patent · US Expired

Removal of viruses from protein solutions by ultrafiltration

US6391657B1 · kind B1 · utility

2Cited by

5References

15Claims

0Family size

Assignee

Aventis Behring GmbH · DE

Inventors

Dieter Bernhardt · Cölbe, DE
Albrecht Groner · Seeheim-Jugenheim, DE
Thomas Nowak · Staufenberg, DE

Key dates

Filing date	Feb 7, 1996
Grant date	May 21, 2002
Priority date	—
Expiry date	Feb 7, 2016

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K1/34
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to the removal of viruses from aqueous solutions, as a rule protein solutions, by ultrafiltration. This entails the viruses to be removed being increased in size by incubation with a high molecular weight receptor binding thereto, preferably a specific antibody, so that, on the one hand, the separation effect is improved and, on the other hand, a larger pore diameter which can now be chosen for the filters used also makes it possible for smaller viruses to be separated from larger protein molecules present in protein solutions, and, where appropriate, the filtration rate is increased.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.