Medical emulsion for lubrication and delivery of drugs
US6391832B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 21, 2001 |
| Grant date | May 21, 2002 |
| Priority date | — |
| Expiry date | Jun 21, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B17/320758
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant also includes a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.