Compounds and methods for modulating junctional adhesion molecule-mediated functions
US6391855B1 · kind B1 · utility
20Cited by
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14Claims
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Key dates
| Filing date | Jun 2, 1999 |
| Grant date | May 21, 2002 |
| Priority date | — |
| Expiry date | Jun 2, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for using modulating agents to enhance or inhibit junctional adhesion molecule (JAM)-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. The modulating agents comprise at least one JAM cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the JAM cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.