[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides

US6391859B1 · kind B1 · utility

Assignee

• EMORY UNIVERSITY · US

Inventors

• Raymond F. Schinazi · Decatur, US
• Dennis C. Liotta · Atlanta, US

Key dates

• Filing date: Oct 2, 2000
• Grant date: May 21, 2002
• Expiry date: Oct 2, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3′-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.