(&agr;-aminophosphino) peptides derivative and compositions containing same

US6391866B1 · kind B1 · utility

Assignee

• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Bernard Roques · Paris, FR
• Marie-Claude Fournie-Zaluski · Paris, FR
• Xuixiong Chen · Bagneux, FR

Key dates

• Filing date: Feb 9, 2001
• Grant date: May 21, 2002
• Expiry date: Feb 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/3211
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns (&agr;-aminophosphino) peptide derivative compounds of general formula (I) wherein: R1 and R2 represent each a hydrogen atom or together form an imine with the adjacent nitrogen atom; R3 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all said groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally a methyl group substituted by an aromatic or saturated heterocyclic group; R4 represents a CH(X)—(O)—C(O)—Y group or a CH2CH2—S—C(O)—W group; R5 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all said groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally a methyl group substituted by an aromatic or unsaturated heterocyclic group; R6 and R7 can in particular represent a hydrogen atom, an alkyl group, a phenyl group substituted or not; R8 represents an alkyl, alkenyl, phenyl or benzyl group; n=0 or 1, in the form of enantiomers, diastereoisomers or racemic mixtures, their salts, the method for preparing them and their therapeutic applications.